lmmunocytochemical Localization of the Neuron-Specific Form of the C-SK Gene Product, pp60c-sfc(+), in Rat Brain
نویسندگان
چکیده
‘Department of Microbiology, SUNY at Stony Brook, Stony Brook, New York 11794, 2Howard Hughes Medical Institute and Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, 3Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, and 4Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021
منابع مشابه
Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain.
Neurons express high levels of a variant form of the c-src gene product, denoted pp60c-src(+), which contains a 6 amino acid insert in the amino-terminal half of the c-src protein. We have determined the localization of pp60c-src(+) in neurons using an affinity-purified anti-peptide antibody, referred to as affi-SB12, that exclusively recognizes this neuron-specific form of the c-src gene produ...
متن کاملHuman chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density
Objective(s): Amyloid β plaques, in Alzheimer’s disease, are deposits in different areas of the brain such as prefrontal cortex, molecular layer of the cerebellum, and the hippocampal formation. Amyloid β aggregates lead to the release of cytochrome c and finally neuronal cell death in brain tissue. hCG has critical roles in brain development, neuron differentiation, and function. Therefore, we...
متن کاملConstruction of T-vector derived from pBluescript ΙΙ SK with a positive selection marker, a rapid system for cloning
A rapid DNA cloning system is a research interest of many scientists. TA cloning is one of the methods used for the cloning of PCR-amplified DNA molecules. The TA cloning method is a convenient and labor-saving replacement to traditional, restriction enzyme-mediated cloning strategies. A T-vector called pBlueskript ΙΙ SK-1 with the lethal gene ccdB was designed to construct a positive selection...
متن کاملDopamine-Synthesizing Neurons: An Overview of Their Development and Application for Cell Therapy
Cell-gene therapy is a dynamic constituent of novel medical biotechnology. Neurodegenerative disordersin which damage to or demise of specific brain cell types plays central role, are clear examples of diseasecandidate for cell replacement therapy. Dopaminergic (DAergic) neurons biosynthesize dopamine, a vitalneurotransmitter in the central nervous system. Due to the involveme...
متن کاملThe Effect of Swimming Endurance Exercise on Cell Death and Nicotinic Acetylcholine Receptor Gene Expression in Brain of Rat: An Experimental Study of Alzheimer's Disease Model
Background and Objectives: Alzheimerchr('39')s disease (AD) is a neurodegenerative disease which is marked by impaired cholinergic function and decreased nicotinic acetylcholine receptor (nAChRs) density. nAChRs are important mediators of cholinergic signaling in modulation of learning and memory function. In Alzheimer hippocampus is particularly vulnerable to specific degenerative processes an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003